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Interstitial mycosis fungoides initially diagnosed as interstitial granulomatous drug reaction

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Interstitial mycosis fungoides initially diagnosed as interstitial granulomatous drug reaction

Auteurs : Karyn Fuller [Australie]

Source :

RBID : ISTEX:DC749F4B7FEBAAE08931D686FF27EAE5DC446F4A

English descriptors

Abstract

A 74 year old woman presented with a 1‐month history of symmetrical erythematous annular plaques involving her groin and medial thigh 3 to 4 years post commencing simvastatin. Initial histology was consistent with the diagnosis of interstitial granulomatous drug reaction (IGDR), however 11 months post cessation of Simvastatin the plaques were expanding in size. Repeat biopsy demonstrated features of interstitial mycosis fungoides (IMF). IMF is a rare variant of mycosis fungoides. It has been reported to resemble granuloma annulare, inflammatory morphoea and IGDR with an interstitial lymphocytic infiltrate. IGDR presents most commonly with a history of asymptomatic, erythematous to violaceous plaques in an annular pattern, mainly involving the intertriginous areas, medial thighs and inner aspects of the arms. There is a temporal association between the initiation of drug therapy and lesional onset and resolution after cessation of the drug. It has clinical and histological features that overlap with IMF. This case of a rare variant of mycosis fungoides initially diagnosed as interstitial granulomatous drug reaction is presented to highlight the importance of recognising this differential diagnosis when presumed IGDR fails to resolve.

Url:
DOI: 10.1111/j.1440-0960.2006.00311_1.x


Affiliations:


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Le document en format XML

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<term>Malignant</term>
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<term>Mycosis fungoides</term>
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